CN code 292249 covers amino acids other than glutamic acid (292242) and lysine (292241), together with their esters and salts, not falling within more specific subheadings of Chapter 29. The group includes glycine (CAS 56-40-6), L-alanine (CAS 56-41-7), L-valine (CAS 72-18-4), L-leucine (CAS 61-90-5), L-isoleucine (CAS 73-32-5), gamma-aminobutyric acid (GABA, CAS 56-12-2), taurine (CAS 107-35-7), L-tyrosine (CAS 60-18-4), and L-tryptophan (CAS 73-22-3). Glycine is the simplest amino acid and is used as a buffering agent, a component of infusion fluids, a dietary supplement ingredient, and a preservative in cosmetics. Taurine is an organic sulphonic acid of particular importance in energy drinks and animal nutrition. GABA functions as an inhibitory neurotransmitter and is marketed as a dietary supplement ingredient promoting relaxation and sleep quality. All substances classified under this code must be chemically defined compounds pursuant to Note 1 to Chapter 29; amino acid mixtures or amino acid preparations are generally classified in Chapter 21 or Chapter 38.

Amino acids covered by CN 292249 imported into the EU are subject to REACH Regulation (EC) No 1907/2006. Registration with ECHA or appointment of an Only Representative (OR) is required for each substance imported in quantities of at least 1 tonne per year by a single importer. The CLP hazard profile of most amino acids in this group is relatively low – glycine, alanine, and valine are not classified as hazardous under standard commercial applications. An exception may be L-tryptophan, for which historical contamination incidents have highlighted the need for stringent microbiological and chemical purity controls. Taurine and GABA in powder form may cause respiratory irritation upon dust inhalation, making respiratory protection advisable during bulk handling. A Safety Data Sheet (SDS) prepared in accordance with Regulation (EU) 2020/878 is mandatory for each industrial substance regardless of hazard profile. Amino acids used in dietary supplements are additionally regulated by Regulation (EC) No 1925/2006 and, in the case of novel forms or sources, by Regulation (EU) 2015/2283 on novel foods.

Customs declarations under CN 292249 must state the full chemical name (IUPAC nomenclature preferred), stereochemistry (e.g. L or D form), CAS number, degree of purity, and description of commercial form (e.g. crystalline powder, granulate, aqueous solution). For amino acids intended for pharmaceutical applications, compliance documentation with pharmacopoeia standards (Ph.Eur., USP) and a manufacturer GMP certificate are required. Amino acids for use in animal nutrition must comply with Regulation (EC) No 1831/2003 on additives for use in animal nutrition and hold EU authorisation for use in the relevant animal species. Imports from third countries should be checked to confirm the substance is not subject to export sanctions or restrictions in the country of origin. Preferential tariff rates may be available under applicable FTA agreements – TARIC verification and correct preparation of EUR.1 certificates or invoice declarations are recommended before order placement. Where the manufacturing substrate is of animal origin, a TSE/BSE-free declaration from the manufacturer should be obtained for pharmaceutical and nutraceutical applications.

Organic substances under CN code 2922 49 (Other amino acids and their esters) require detailed chemical documentation for customs clearance. The Safety Data Sheet must comply with REACH Annex II. Substances classified as hazardous under CLP require GHS pictogram labelling. Transport follows ADR (road) or IMDG (maritime) regulations. Some organic substances may be subject to export controls as dual-use goods. Importers should verify whether the substance requires REACH authorisation (Annex XIV) or is subject to restrictions (Annex XVII).